Effects of surface roughness of ceria-stabilized zirconia/alumina nanocomposite on the morphology and function of human gingival fibroblasts

We evaluated the biological effects of implant abutments made from ceria-stabilized zirconia/alumina nanocomposite (Ce-TZP/Al2O3) with surface roughness variations using human gingival fibroblasts (HGF-1) in transmucosal region. Two types titanium (Ti) and Ce-TZP/Al2O3 disks different profiles were prepared (Ra0.9 Ra0.02). Surface properties SEM, EDX, wettability analysis. Biological parameters including cell adhesion, proliferation morphology, collagen deposition, inflammatory cytokine expression for each disk. morphology analysis Ti elucidated uniform linear structures Ra0.9 smooth flat Ra0.02. Cell showed spindle-shaped large, circular forms, respectively. adhesion deposition significantly increased on Ra0.02 disk compared others, no significant differences among all disks. The reduced was advantageous promoting